Job description
Site Name: UK - Hertfordshire - Stevenage, Cambridge 300 Technology Square, USA - Pennsylvania - Upper Providence
Posted Date: Nov 28 2025

We are seeking an experienced, motivated and innovative individual to join us as a Principal Scientist / Associate Director in Statistical Pharmacogenetics in the Translational & Clinical Genetics team, which is part of the broader GSK Human Genetics and Genomics organisation.� The successful candidate will design and deliver hands-on pharmacogenetic statistical analyses of clinical trial data, working in cross-functional teams to impact the GSK portfolio.�� You will have strong expertise in genetics, experience of undertaking genetic analysis of biobanks/observational cohorts and/or clinical trial data and enjoy working in cross-functional teams.� You will have experience of a range of statistical genetic analyses including genome-wide single variant testing, burden testing, and investigating polygenic risk scores. You should also have experience in additional omics data (e.g., proteomics) and integrating it with genetics to generate novel translational insights in biobanks/observational cohorts or clinical trial data.

The successful candidate will work directly with colleagues in Human Genetics and Genomics and closely with a range of other stakeholders in cross-functional teams, including but not limited to clinical statisticians and biomarker project leads. You will have the opportunity to work in and gain experience of different therapeutic areas through working on specific projects in clinical development and, where appropriate, potentially help clinical teams to incorporate pharmacogenetics into new clinical studies.� There may be opportunity for you to identify, establish and drive collaborations with external institutions aligned with strategic priorities.� Additionally, you will be encouraged and supported in the ongoing development of your scientific expertise through your impactful work and its visibility to key stakeholders, completing development programmes, presenting your research and writing peer-reviewed publications. Overall, this is an exciting opportunity to undertake impactful genetic analyses working in a dynamic setting to help us better understand the medicines we�re developing.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

We are open to hiring at both a G7 and G6 level.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will:

• Conduct hands-on pharmacogenetic analyses of clinical trials.
• Design and author statistical analysis plans and pharmacogenetic reports.
• Collaborate and work closely with colleagues in cross-functional teams to oversee the development and timely delivery of pharmacogenetic analyses and reports.
• Perform a range of statistical genetic analyses including, but not limited to, power calculations, single variant tests, burden tests, and polygenic risk scores.
• Integrate genetics and other omics data in analyses to gain novel translational insights.
• Understand the strengths and limitations of different statistical genetic analyses for pharmacogenetics.
• Evaluate and implement new methodologies and technologies to improve the efficiency and effectiveness of genetic analyses.
• Ensure compliance with relevant regulations and guidelines in the field of pharmacogenetics.
• Assist clinical teams to incorporate pharmacogenetics into new clinical studies that are being designed and set up

Why you?

Qualifications & Skills:

We are looking for a professional with these required skills to achieve our goals:

• PhD or equivalent advanced degree in a relevant scientific discipline (e.g. statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics) with a history of impactful scientific publications and/or presentations.
• Expertise in statistical genetics
• Experience of conducting genetic analyses of clinical trial data or other human genetic datasets (e.g., biobanks, observational cohorts).
• Strong written communication skills to design and write pharmacogenetic statistical analysis plans and reports.
• Strong proficiency in at least one of R and Python, with experience of writing reproducible and scalable code that abides to FAIR principles.
• Excellent collaboration and partnership skills to work effectively within internal teams and with internal stakeholders across functions.�
• Demonstrated experience of effectively communicating complex scientific concepts to diverse audiences.
• Demonstrated ability to work effectively both independently and in multidisciplinary teams to meet project timelines.

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

• Extensive experience in genetics and preferably conducting analyses that integrate genetics with other omics data to generate novel translational insights.�
• Familiarity with the common statistical approaches used to analyse clinical trials
• Experience of project management is desirable to enable oversight of pharmacogenetic studies from registration to archiving��
• Familiarity with the stages of drug discovery and development
• Experience working in the pharmaceutical industry

Closing Date for Applications: 12th December 2025 EOD

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the �cover letter� of the online application and your CV to describe how you meet the competencies for this role, as outlined in the job requirements above.

The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people�s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients� needs and have the highest probability of success. We�re uniting science, technology, and talent to get ahead of disease together.

Find out more:
Our approach to R&D

We are seeking an experienced, motivated and innovative individual to join us as a Principal Scientist / Associate Director in Statistical Pharmacogenetics in the Translational & Clinical Genetics team, which is part of the broader GSK Human Genetics and Genomics organisation.� The successful candidate will design and deliver hands-on pharmacogenetic statistical analyses of clinical trial data, working in cross-functional teams to impact the GSK portfolio.�� You will have strong expertise in genetics, experience of undertaking genetic analysis of biobanks/observational cohorts and/or clinical trial data and enjoy working in cross-functional teams.� You will have experience of a range of statistical genetic analyses including genome-wide single variant testing, burden testing, and investigating polygenic risk scores. You should also have experience in additional omics data (e.g., proteomics) and integrating it with genetics to generate novel translational insights in biobanks/observational cohorts or clinical trial data.

The successful candidate will work directly with colleagues in Human Genetics and Genomics and closely with a range of other stakeholders in cross-functional teams, including but not limited to clinical statisticians and biomarker project leads. You will have the opportunity to work in and gain experience of different therapeutic areas through working on specific projects in clinical development and, where appropriate, potentially help clinical teams to incorporate pharmacogenetics into new clinical studies.� There may be opportunity for you to identify, establish and drive collaborations with external institutions aligned with strategic priorities.� Additionally, you will be encouraged and supported in the ongoing development of your scientific expertise through your impactful work and its visibility to key stakeholders, completing development programmes, presenting your research and writing peer-reviewed publications. Overall, this is an exciting opportunity to undertake impactful genetic analyses working in a dynamic setting to help us better understand the medicines we�re developing.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will:

• Conduct hands-on pharmacogenetic analyses of clinical trials.
• Design and author statistical analysis plans and pharmacogenetic reports.
• Collaborate and work closely with colleagues in cross-functional teams to oversee the development and timely delivery of pharmacogenetic analyses and reports.
• Perform a range of statistical genetic analyses including, but not limited to, power calculations, single variant tests, burden tests, and polygenic risk scores.
• Integrate genetics and other omics data in analyses to gain novel translational insights.
• Understand the strengths and limitations of different statistical genetic analyses for pharmacogenetics.
• Evaluate and implement new methodologies and technologies to improve the efficiency and effectiveness of genetic analyses.
• Ensure compliance with relevant regulations and guidelines in the field of pharmacogenetics.
• Assist clinical teams to incorporate pharmacogenetics into new clinical studies that are being designed and set up

Why you?

Qualifications & Skills:

We are looking for a professional with these required skills to achieve our goals:

• PhD or equivalent advanced degree in a relevant scientific discipline (e.g. statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics) with a history of impactful scientific publications and/or presentations.
• Expertise in statistical genetics
• Experience of conducting genetic analyses of clinical trial data or other human genetic datasets (e.g., biobanks, observational cohorts).
• Strong written communication skills to design and write pharmacogenetic statistical analysis plans and reports.
• Strong proficiency in at least one of R and Python, with experience of writing reproducible and scalable code that abides to FAIR principles.
• Excellent collaboration and partnership skills to work effectively within internal teams and with internal stakeholders across functions.�
• Demonstrated experience of effectively communicating complex scientific concepts to diverse audiences.
• Demonstrated ability to work effectively both independently and in multidisciplinary teams to meet project timelines.

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

• Extensive experience in genetics and preferably conducting analyses that integrate genetics with other omics data to generate novel translational insights.�
• Familiarity with the common statistical approaches used to analyse clinical trials
• Experience of project management is desirable to enable oversight of pharmacogenetic studies from registration to archiving��
• Familiarity with the stages of drug discovery and development
• Experience working in the pharmaceutical industry

Closing Date for Applications: 12th December 2025 EOD

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the �cover letter� of the online application and your CV to describe how you meet the competencies for this role, as outlined in the job requirements above.

The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people�s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients� needs and have the highest probability of success. We�re uniting science, technology, and talent to get ahead of disease together.

Find out more:
Our approach to R&D

� If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $146,850 to $244,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate�s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases � to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we�re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391.� The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK�s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

����

Job description
Site Name: UK - Hertfordshire - Stevenage, Belgium-Wavre, Mississauga, USA - Pennsylvania - Upper Providence, Warsaw
Posted Date: Dec 4 2025

Company Overview

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people�s lives.�GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients� needs and have the highest probability of success. GSK has kicked off 2025 with impressive growth in sales, profits, and earnings. We anticipate five major new FDA product approvals and 15 phase III/pivotal study readouts over the next two years. So far, we have secured two FDA approvals, with three more expected later this year. By uniting science, technology, and talent, we are committed to getting ahead of disease together.�

Job Purpose

GSK is seeking an experienced leader to support the Non-Interventional Studies Planning & Delivery Study Delivery Leadership Team on implementing and executing the oversight on Study Delivery FSP resourcing strategies with third parties within the NIS P&D organisation. This role is fully accountable for managing the overall delivery, cost and quality of projects and contracts assigned to meet organisational expectations, to enable efficient and cost-effective delivery of NIS P&D Study Delivery FSP resourcing model for the NIS P&D organisation. Management of the budget to meet the relevant budget targets and ensure it is in line with the wider clinical operations targets.

Key Responsibilities:

• Lead and manage the operationalization of the NIS P&D Study Delivery FSP model, ensuring strategic oversight, governance, and continuous improvement in collaboration with internal and external stakeholders.

• Oversee design, implementation, and transition to the FSP operating model.

• Build and maintain strong partnerships with FSP vendors for seamless program delivery.

• Drive process improvements and strategic enhancements to FSP models.

• Ensure compliance with governance frameworks, contracts, and financial controls.

• Liaise with Procurement, HR, Legal, Finance, and CRO managers to align with business expectations.

• Monitor KPIs, risks, and cost-saving measures; escalate issues through governance structures.

• Act as primary liaison for issue resolution across processes, countries, and study-level concerns.

• Provide operational guidance on systems onboarding, training, and WoWs.

• Implement initiatives to improve study delivery performance and team capability.

• Serve as business owner for all FSP services, including budget oversight and legal documentation.

Why you?

Basic Qualifications:

• Bachelor�s degree or equivalent in General Science or Life/Health related Science Degree

• Extensive experience in managing clinical operations with strong knowledge and experience of Non-Interventional Studies (NIS).

• In-depth knowledge of study management, essential regulatory guidelines worldwide, and the clinical development process.

• Experience in People Management and management of resources from different sources in different locations (internal, external, functional service providers).

• Experience in management of Third Parties

Preferred Qualifications:

• Advanced degree in General Science or Life/Health related Science Degree

• Excellent knowledge and understanding of clinical operations and activities associated to study delivery.

• Excellent knowledge ICH-GCP and Regulations.

• Knowledge of Industry and CRO world. Experience working with functional service providers.

• Excellent customer orientation, ability to work beyond silos with a strong service provider mindset

#LI-GSK*

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases � to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we�re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391.� The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK�s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

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Job description
Site Name: UK - Hertfordshire - Stevenage
Posted Date: Nov 28 2025

Do you share a desire to advance scientific knowledge and�capitalise on the revolution in data, automation and predictive sciences to deliver measurable impacts on the success and progression of GSK�s medicine discovery portfolio?

The Data, Automation and Predictive Sciences (DAPS) function of GSK Research Technologies focuses on large-scale data generation, curation, analysis and prediction to deliver higher PTRS (Probability of Technical and Regulatory Success) assets and unlock upper quartile ambitions. Within DAPS, the Discovery Integration Sciences team is driving efforts across Research to build the world�s most efficient and effective biopharma discovery platform at GSK by building and deploying innovative Lab-in-an-Automated-Loop (LIAL) Systems that integrate computational intelligence with physical laboratory experimentation in adaptive learning cycles. Each LIAL System will deliver a domain leading scientific discovery solution that leverages and extends state-of-the-art scientific methods by engineering technologies to create integrated discovery systems that empower GSK research scientists with the latest tools. LIAL Systems will therefore be physical instantiations of GSK�s mission to unite science, technology and talent to get ahead of disease together.

The foundation of efficient and effective biopharma discovery, grounded in decision making on the aetiological relevance of targets and mechanisms in disease, is an integrated causal mechanistic understanding of disease. Experiments executed using LIAL Systems generate data that through analysis can extend this foundational knowledge to understand how potential drug molecules alter biological mechanisms and change the course of disease. It is essential that we effectively integrate foundational causal biology understanding with knowledge generated through discovery activities to select assets with higher PTRS.

As Associate Director, Integrated Scientific Data Analysis & Visualization in the Discovery Integration Sciences team, you will be responsible for leading activities to integrate GSK�s foundational causal biology data with data generated through discovery processes and make the resulting data products Findable, Accessible, Interoperable, and Reusable (FAIR) and available to R&D scientists, both directly through visualizations/interfaces and via agentic systems for real-time decision making. In this role, you will work and lead across scientific and technical disciplines with a strong focus on causal mechanistic understanding to deliver impactful solutions, build trusting relationships and realize lasting business value in a matrix environment.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

This position is based 2-3 days per week in Stevenage or London

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will

• Design and deliver scientific visualizations and underlying data structures to surface multi-modal scientific data generated across biopharma discovery activities in an integrated and actionable manner based on a causal mechanistic representation of disease.
• Build, test and optimise robust and performant scientific visualizations and applications that enable real time exploration of large-scale interconnected data packages managed on GSK�s Onyx Research Data Platform and the capture of human insight.
• Collaborate across departments, with scientists evaluating integrated data packages to progress the portfolio, and with data, knowledge and software engineers, to enable robust knowledge foundations and maturation of best-in-class visualizations into production applications.
• Contribute to a culture of innovation, quality, and continuous learning and improvement within the team, including mentoring or upskilling other team members and continuously evaluating bioinformatics science and technology developments for potential application at GSK.
• Understand the internal and external landscape of data integration, visualization and access principles to build identify and create high-value scientific visualizations.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• Bachelor�s degree (or equivalent) in Computer Science, Data Science, Software Engineering, Life Sciences or related field.
• Extensive experience in scientific data analysis and visualization, with a strong preference for experience in pharma/biotech.
• Extensive experience in front end technologies: JavaScript, Typescript, ReactJS, AngularJS or similar.
• Extensive experience with at least one common web backend language: e.g. Python, Scala, Java, Javascript (Node.js) including toolchains for documentation testing and operations/observability.
• Extensive experience with modern software development tools and ways of working (e.g. git/GitHub, DevOps tools, metrics/monitoring, �).
• Extensive experience building complex scientific data visualizations using visualization frameworks like D3.js, Plotly, Matplotlib, or similar.
• Extensive experience building and visualizing complex scientific data assets with semantically designed schemas leveraging relational and graph technologies.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Specific experience with Knowledge Graph efforts.
• Experience with open-source ontology tools, data formats and languages (e.g. prot�g�, SPARQL, OWL, SKOS, SHACL, RML).
• Demonstrated experience establishing and managing external partnerships in an industrial setting.
• Track record of change leadership driving lasting adoption of scientific analysis and visualization tool within an organization.

Closing Date for Applications � 12th December 2025 (EOD)

Please take a copy of the Job Description, as this will not be available post closure of the advert.�

When applying for this role, please use the �cover letter� of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people�s lives.?GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients� needs and have the highest probability of success. We�re uniting science, technology, and talent to get ahead of disease together.

Find out more: �

Our approach to R&D.???

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases � to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we�re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391.� The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK�s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

����

Job description
Site Name: USA - North Carolina - Durham, UK - London
Posted Date: Dec 4 2025

ViiV Healthcare is a global specialty HIV company, the only one that is 100% focused on researching and delivering new medicines for people living with, and at risk of, HIV. ViiV is highly mission-driven in our unrelenting commitment to being a trusted partner for all people living with and affected by HIV. Our aim is to think, act, and connect differently through a focus on education on and treatment for HIV.� We go to extraordinary lengths to deliver the sorts of breakthroughs, both in treatments, care solutions and communities, that really count. We go beyond the boundaries of medicine by taking a holistic approach to HIV through developing and supporting sustainable community programs and improving access to care.� We are fully committed to push through every challenge until HIV/AIDS is eradicated. ViiV has played a significant part in delivering breakthroughs that have turned HIV into a manageable health condition. We offer the largest portfolio of HIV medicines available anywhere, and we continue our work to cater for the widest possible range of needs in response to the HIV epidemic.

We are aware of how much is at stake for those affected by HIV and we show up every day 100% committed to the patients. Our work culture is fast-paced, diverse, inclusive, competitive, and caring. But ViiV isn�t just somewhere to work � it�s a place to belong, an invitation to bring your very best, and a team full of impact-driven team members who are hungry to make a difference.

While we have been improving lives of HIV patients for 30 years, this is an especially exciting time to be at ViiV, as we evaluate novel approaches to treatment and prevention that could further reduce the impact of HIV on individuals and communities.

The Global Medical Affairs Senior Director is responsible for establishing global medical and scientific strategic direction, short- and long-term goals, and leadership for the overall planning and delivery of integrated medical affairs plans for PrEP. This includes managing global medical affairs activities/initiatives and overseeing internal (Medical, Commercial, Regulatory, Compliance, Legal, VHL LOCs) and external (healthcare professionals, advocacy groups, partner organisations, and HIV prevention communities) stakeholders. The role is pivotal in ensuring the success of PrEP strategies, supporting ViiV/GSK�s mission to reduce HIV incidence globally.

This role will be based out of ViiV's US Headquarters in Durham, NC (RTP Area) OR GSK Headquarters in London, UK & may be considered for a domestic relocation package.�Check out this link to learn more about the thriving, diverse, and cutting edge RTP area!

Research Triangle Park | Where People + Ideas Converge (rtp.org)

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Build and maintain effective relationships and provide scientific expertise to clinical, commercial, regulatory, compliance, and legal teams to ensure the creation and delivery of scientifically accurate and compliant medical data.

• Lead the development, implementation, and execution of the global medical strategy and integrated evidence plan for PrEP, spanning pre-launch to post-launch phases.

• Number of Direct Reports: 2

• Number of Indirect Reports: 0

• Assets Managed: PrEP portfolio

• Operating Budget Accountability: No direct budget; responsible for delivery within allocated resources

• Oversee and support Investigator Sponsored Study (ISS) management and advisory board execution for PrEP.

• Maintain a high level of knowledge and expertise in the external regulatory and ethical environment, ensuring compliance with ABPI/PMCPA and other relevant codes.

• Partner with the Scientific Communications Lead to develop and deliver a global medical communication plan, ensuring consistency across all regions.

• Provide direct expertise and facilitate medical scientific team expertise to external experts (KOLs, HCPs, payers, patients) and internal stakeholders.

• Support the development of innovative content, tools, and resources to drive awareness and adoption of PrEP among HCPs and consumers.

• Ensure the alignment, maintenance, and communication of all cross-functional Pharma & R\&D policies and procedures that support the production and delivery of medical information.

• Lead and coordinate the Integrated Evidence Team for PrEP.

• Line manage direct reports as required, ensuring delivery of global medical affairs activities for PrEP.

Why You?

Basic Qualification
We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• BS degree in a medical OR clinical area (Infectious Diseases/HIV)

• HIV specialist clinical practice and pharmaceutical industry experience

• ABPI OR equivalent Code of Practice reviewer/signatory

• Experience working with commercial operations and cross functionally

• Experience influencing peers and managing indirect reports across a matrix organisation

• External scientific presentation experience

• Experience with pharmaceutical drug development

• Experience managing multiple priorities and projects

• Willingness to travel for internal and external business meetings

Preferred Qualification
If you have the following characteristics, it would be a plus:

• MSc/PhD/MD/PharmD (Infectious Diseases/HIV)

• Strong team working and relationship-building skills

• Excellent communication and negotiation capabilities

• Results orientation with an entrepreneurial approach

• Innovation in management methods and technology to build new business opportunities and value

• Strong customer orientation/focus

• Ability to work effectively in multidisciplinary teams and cultivate collaborative relationships

• Strong business acumen and understanding of industry dynamics

#LI-ViiV

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program ViiV offers US employees. All ViiV employees receive the same benefits options and plans as GSK employee.

Why Us?

At ViiV Healthcare, we will not rest until we leave no person living with HIV behind. Until the 39 million people living with HIV is down to zero, we will continue searching for new ways to limit the impact of HIV.�

We are the only pharmaceutical company solely focused on combating, preventing, and ultimately eradicating HIV and AIDS. At ViiV Healthcare, we do things differently. Born out of a partnership between GSK and Pfizer in 2009, with Shionogi joining in 2012, we are determined to help end the HIV epidemic. We are guided by our mission to leave no person living with HIV behind and it is this mission that unites our employees located across the globe. We combine expertise in research, manufacturing, policy and more to push the boundaries of what people think is possible in HIV treatment and care. As a result of our connection with GSK, we are able to draw on their proud history and resources. This means that you would receive all the employee benefits offered by GSK.

Living our mission of leaving no person living with HIV behind means keeping inclusion and diversity at the heart of everything we do - from our breakthrough innovation, to our diverse portfolio of medicines as well as the work we do to partner with HIV communities. Having a�truly inclusive culture where we�re all able to be ourselves and feel like we belong will make us an even stronger team, better able to perform as a business and deliver on our mission to leave no person living with HIV behind.

If you require an accommodation or other assistance to apply for a job at ViiV, please contact the ViiV Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

ViiV is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies

ViiV does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact ViiV's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to ViiV. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and ViiV. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ViiV. ViiV shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, ViiV may be required to capture and report expenses ViiV incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure ViiV�s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

Job description
Site Name: UK - Hertfordshire - Stevenage, UK � London � New Oxford Street, USA - Massachusetts - Waltham, USA - Pennsylvania - Upper Providence
Posted Date: Dec 2 2025

�

The Department of Clinical Pharmacology and Quantitative Medicine (CPQM) in�Respiratory, Immunology and Inflammation Research Unit,�R&D GSK is recruiting for an Associate Director-level Quantitative Systems Pharmacologist Lead to join the Quantitative Systems Pharmacology team.�The CPQM at GSK is a newly established organization with the remit to become a�Centre of Excellence in Model-Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modeling.�

The convergence of science and technology is changing discovery and development at GSK, allowing us to make advances on behalf of patients that were once thought impossible. Our R&D organization is delivering more innovation, better and faster, using new data and platform technologies that speed discovery and development and improve the chance of success.�

This position represents an opportunity for professionals with PhD, MD, PharmD or equivalent doctoral background, who are experienced mechanistic modelers with experience in QSP and/or QST modelling, clinical pharmacology and pharmacometrics to advance the vision and mission of GSK�s rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio. Sought after experiences for this position include building mechanistic mathematical models and leveraging the knowledge in the areas of scientific ML, inverse problems, AIML and/or statistical methodologies, to enhance the robustness and quality of model development to leverage for decision-making from exploratory research through clinical development.��You will be expected to play a critical role in the day-to-day driving integration of end-to-end model-informed drug discovery and development through building and applying QSP and QST models. In addition, you will be facilitating of defining, implementing and coordinating�QSP and QST related Clinical Pharmacology and Quantitative Medicine development strategies for disease and therapeutics of interest, and providing expert input into the clinical pharmacology evidence generation and integrated evidence plans in the Disease therapeutic area. �

This is an exciting opportunity to bring your vision to a new era of digital innovation in clinical pharmacology and quantitative medicine, profoundly impacting patient outcomes and shaping the future of R&D at GSK.�

Key Responsibilities:

• Establish by building or guiding mathematical model development to understand disease, its progression, and drug action to prevent, treat and cure diseases; conduct simulations to assess trial design performance��
• Utilize mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities�
• Develop and/or utilize state-of-the-art mathematical tools including knowledge of inverse-problem modelling and simulation, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction�
• Facilitate defining and executing a coordinated scientific and technical strategy (18-24 months planning horizon) with demonstrated ability to co-ordinate outputs from several expertise areas to determine strategy��
• Work in close collaboration with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms��
• Implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline��
• Able to interact with line and middle management, staff and external contacts on a functional, strategic and tactical level��
• Promote transparency and communicate R&D achievements through publications in appropriate scientific journals�

?�

Why you?��

Basic Qualifications:��

We are looking for a professional with these required skills to achieve our goals:���

• PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology with applications in pharmaceutical research and development��
• Strong drive and agility to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention,�treatments, and trial design�
• Experience in mechanistic mathematical modeling, inverse problem modeling and simulation, and/or scientific machine learning methodologies to apply to pre-clinical and/or clinical questions in drug development to solve practical problems in pharmaceutical industry��
• Demonstrated aptitude for productive collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results��
• Clear evidence of ability to make sound judgement in complex situations and adapt to changing business needs by prioritizing multiple tasks��
• Prior experience in Respiratory, Hepatology and/or Infections diseases is a plus�

Closing Date for Applications � 09 Dec 2025 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.�
When applying for this role, please use the �cover letter� of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

?�

� If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $137,775 to $229,625. The US salary ranges take into account a number of factors including work location within the US market, the candidate�s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases � to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we�re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391.� The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK�s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

����

Job description
Site Name: USA - Pennsylvania - Philadelphia, Belgium-Wavre, UK - London, USA - Massachusetts - Waltham, USA - North Carolina - Durham
Posted Date: Nov 13 2025

The Director, Real-World Biostatistics is a key role focused on advancing strategy and methodology in the entire course of drug/vaccine development using real-world data (RWD) within the enterprise. This position requires providing deep biostatistical expertise, strategic insight, and supporting methodological innovation to enhance the development and commercialization of pharmaceutical products, primarily in the oncology research unit (RU).

The Director will design and analyze RWD studies and other observational studies using cutting-edge biostatistical methodologies associated with causal inference and comparative effectiveness, clinical outcomes assessment, longitudinal and predictive modelling, and target trial emulation, while also mentoring staff assigned to these projects.�

Key Responsibilities:

Biostatistical and Methodologic Support:

• Lead and oversee the execution of real-world studies, ensuring methodological rigor, quality control, and regulatory adherence.
• Create and refine statistical analysis plans, conduct complex statistical analyses, and convey findings to internal and external stakeholders.
• Apply fit for purpose non-interventional statistical methods tailored to specific study objectives, ensuring robust data interpretation and insight generation.

Therapy Area Knowledge:

• Understand RU/assets to apply appropriate tools (e.g., variable definitions, code lists) and data sources and leverage hands on with RWD expertise to guide the selection and appropriate use of complex health data sets, including experience authoring technical specification documents
• Develop in-depth knowledge on the assigned asset(s) and act as senior-level RWB consultant on matrix teams

Project Management and Staff Mentorship:

• Mentor junior staff, guiding and developing their capabilities through mentorship, training, and professional growth opportunities while promoting knowledge sharing, continuous learning, and an innovative and collaborative environment.
• Lead statistical efforts for assigned projects, manage timelines, resources, quality control, and coordinate across departments (e.g. epidemiology, health economics and outcomes research, clinical).

Communication and Strategic Initiatives:

• Engage in strategic communication within the organization and with external audiences presenting statistical analyses and insights clearly and effectively at conferences, in publications, and during key stakeholder meetings, reinforcing the value of biostatistical contributions.

Methodological Development and Innovation:

• Stay informed on industry trends, incorporate emerging biostatistical methods to enhance study designs and analytics, and participate in methodological research for the development of analytical techniques.

Regulatory Support and Compliance:

• Provide biostatistical expertise on RWD during regulatory submissions, meeting preparations, and addressing queries to ensure alignment with regulatory standards while offering statistical guidance for organizational decision-making processes.
• Stay informed with guidance documents from regulators to industry on use of RWD for regulatory decision-making

Why you?

Basic Qualifications:

• Ph.D. in Biostatistics, Statistics, Epidemiology or related disciplines with 8+ years (or Masters plus 10+ years) of working within the pharmaceutical/biotech industry (preferably in real-world evidence, epidemiology, or health outcomes functional areas)
• Experience working with drug development processes and strategies, utilizing innovative statistical skills to meet project and/or business objectives
• Experience leading pharmacoepidemiology and/or health outcomes analytics using RWD(e.g, electronic health record; insurance claims; registries) and applying observational study design and biostatistical principles to clinical/epidemiological research
• Proficiency in programming languages (e.g., R, Python) and applied experience with observational data.
• Experience in working according to regulatory requirements pertaining to RWD and clinical trials.
• Experience in managing projects, delivering results in matrixed environments.
• Experience in methodological research with contributions to publications in real-world data analytics.

Preferred Qualifications:

• Experience in causal inference methodology such as propensity score based approaches, doubly-robust estimations including target maximum likelihood estimation (TMLE), principal stratification/instrumental variable approaches, methods for time-varying exposures.
• Experience in time-to-event analysis in the setting of non-randomized studies
• Experience in machine learning
• Excellent communication and interpersonal skills for conveying complex statistical concepts effectively.
• Fluency in written and spoken English

#LI-GSK

The US annual base salary for new hires in this position ranges from $174,900 to $291,500 The US salary ranges take into account a number of factors including work location within the US market, the candidate�s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Please visit� GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases � to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we�re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK�s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

Job description
Site Name: UK - Hertfordshire - Stevenage, UK � London � New Oxford Street, USA - Massachusetts - Waltham, USA - Pennsylvania - Upper Providence
Posted Date: Dec 2 2025

�

The Department of Clinical Pharmacology and Quantitative Medicine (CPQM) in�Respiratory, Immunology and Inflammation Research Unit,�R&D GSK is recruiting for an Associate Director-level Quantitative Systems Pharmacologist Lead to join the Quantitative Systems Pharmacology team.�The CPQM at GSK is a newly established organization with the remit to become a�Centre of Excellence in Model-Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modeling.�

The convergence of science and technology is changing discovery and development at GSK, allowing us to make advances on behalf of patients that were once thought impossible. Our R&D organization is delivering more innovation, better and faster, using new data and platform technologies that speed discovery and development and improve the chance of success.�

This position represents an opportunity for professionals with PhD, MD, PharmD or equivalent doctoral background, who are experienced mechanistic modelers with experience in QSP and/or QST modelling, clinical pharmacology and pharmacometrics to advance the vision and mission of GSK�s rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio. Sought after experiences for this position include building mechanistic mathematical models and leveraging the knowledge in the areas of scientific ML, inverse problems, AIML and/or statistical methodologies, to enhance the robustness and quality of model development to leverage for decision-making from exploratory research through clinical development.��You will be expected to play a critical role in the day-to-day driving integration of end-to-end model-informed drug discovery and development through building and applying QSP and QST models. In addition, you will be facilitating of defining, implementing and coordinating�QSP and QST related Clinical Pharmacology and Quantitative Medicine development strategies for disease and therapeutics of interest, and providing expert input into the clinical pharmacology evidence generation and integrated evidence plans in the Disease therapeutic area. �

This is an exciting opportunity to bring your vision to a new era of digital innovation in clinical pharmacology and quantitative medicine, profoundly impacting patient outcomes and shaping the future of R&D at GSK.�

Key Responsibilities:

• Establish by building or guiding mathematical model development to understand disease, its progression, and drug action to prevent, treat and cure diseases; conduct simulations to assess trial design performance��
• Utilize mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities�
• Develop and/or utilize state-of-the-art mathematical tools including knowledge of inverse-problem modelling and simulation, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction�
• Facilitate defining and executing a coordinated scientific and technical strategy (18-24 months planning horizon) with demonstrated ability to co-ordinate outputs from several expertise areas to determine strategy��
• Work in close collaboration with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms��
• Implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline��
• Able to interact with line and middle management, staff and external contacts on a functional, strategic and tactical level��
• Promote transparency and communicate R&D achievements through publications in appropriate scientific journals�

?�

Why you?��

Basic Qualifications:��

We are looking for a professional with these required skills to achieve our goals:���

• PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology with applications in pharmaceutical research and development��
• Strong drive and agility to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention,�treatments, and trial design�
• Experience in mechanistic mathematical modeling, inverse problem modeling and simulation, and/or scientific machine learning methodologies to apply to pre-clinical and/or clinical questions in drug development to solve practical problems in pharmaceutical industry��
• Demonstrated aptitude for productive collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results��
• Clear evidence of ability to make sound judgement in complex situations and adapt to changing business needs by prioritizing multiple tasks��
• Prior experience in Respiratory, Hepatology and/or Infections diseases is a plus�

Closing Date for Applications � 09 Dec 2025 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.�
When applying for this role, please use the �cover letter� of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

?�

� If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $137,775 to $229,625. The US salary ranges take into account a number of factors including work location within the US market, the candidate�s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases � to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we�re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391.� The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK�s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

����

Job description
Site Name: UK - Hertfordshire - Stevenage, GSK HQ, USA - Massachusetts - Waltham, USA - North Carolina - Durham, USA - Pennsylvania - Upper Providence
Posted Date: Dec 4 2025

Clinical Pharmacology Quantitative Medicine (CPQM) is accountable for both applying clinical pharmacology strategies and the principles of quantitative medicine to enable efficient, end-to-end development of transformative medicines.�

A key component of the CPQM mission is to harness the power of AI/ML & mechanistic modelling, to drive robust Development Strategies including Dose, Endpoint & Population Selection; Smart Clinical Trials and deliver Model Informed Drug Development (MIDD) evidence.

Hybrid AIML-Pharmacometrics/QSP methodologies are a set of emerging approaches that combine the power and flexibility of AI/ML with the credibility of mechanistic modelling.� This fusion has the potential to greatly enhance the predictive capabilities of CPQM by enabling the integration of novel data types (e.g. imaging, biomarkers, OMICs, digital endpoints, and real-world data) to drive more predictive and impactful insights for decision-making.

The Manager / Associate Director, MIDD AI/ML Scientist will focus on the practical application of emerging AI/ML and hybrid AI/ML-Pharmacometrics methodologies to projects on an asset and disease level supporting a wide range of clinical development decisions across therapeutic areas.� The role will consist of collaborating with Clinical Pharmacology leads and cross-functional teams to integrate diverse sets of biomedical data (e.g. clinical, imaging, biomarkers, OMICs, digital health, or real-world data) into hybrid AI/ML-Pharmacometrics approaches.� It will consist of analysis planning, execution, interpretation and communication of results.

This position is an excellent entry point for quantitative scientists with a background in AI/ML (e.g. PhDs in AI/ML or related fields) looking to develop expertise at the AI/ML-pharmacometrics interface and apply those techniques to benefit patients at the frontier of medicine.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will:

• Execute portfolio projects: Apply AI/ML and hybrid AI/ML-pharmacometrics approaches to deliver analyses that inform drug development decisions (dose, regimen, endpoint, population, trial design).
• Work cross-functionally: Collaborate with CPMS leads, QSP modellers, statisticians, and digital/imaging experts to integrate AI/ML analyses with existing modelling frameworks.� This will cover developing analysis plans, conducting analyses and communicating interim/final results.
• Drive stakeholder engagement: Proactively interact with stakeholders, line and middle management, staff and external contacts on a functional and tactical level.
• Contribute to our capabilities: Engage with academic groups and external vendors, supporting joint projects and learning cutting-edge methods.� Identify best practices, trends, learnings, etc from internal and external sources
• Drive awareness: Contribute to training, seminars, and internal communications to increase literacy in AI/ML-pharmacometrics.
• Have external influence: Conference presentations, posters, and publications in scientific journals to represent GSK�s impact in AI/ML for drug development.

Why you?

Basic Qualifications & Skills:

We are looking for a professional with these required skills to achieve our goals:

• PhD (or equivalent) in AI/ML or related quantitative fields.
• Strong foundation in AI/ML, statistics or pharmacometrics / quantitative clinical pharmacology.
• Experience coding AI/ML pipelines in Python/Pytorch or Julia/Pumas.�
• Strong interest in developing hybrid AI/ML-pharmacometrics expertise.
• Excellent collaboration and communication skills (written, verbal and presentation), with the ability to work in interdisciplinary teams.

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

• Pharmacometrics experience.
• Experience with AIML approaches to longitudinal data and use of LLMs of agentic AI.
• Experience in developing hybrid AI/ML-pharmacometrics processes.

Join us in this impactful role where your expertise will help ensure patients receive the medicines they need, when they need them.

Closing Date for Applications: 18th December 2025

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the �cover letter� of the online application and your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people�s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients� needs and have the highest probability of success. We�re uniting science, technology, and talent to get ahead of disease together.

Find out more:
Our approach to R&D

� If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $145,200 to $242,000. The US salary ranges take into account a number of factors including work location within the US market, the candidate�s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases � to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we�re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391.� The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK�s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

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